By Peter Scanlon, Stephen Aldington, Charles Wilkinson, David Matthews
This functional medical guide covers the analysis, remedy - either scientific and surgical - and long term administration of eye difficulties in individuals with diabetes. geared toward the MDT concerned about the care of sufferers with diabetes, it emphasizes the significance of standard screening and early prognosis and offers evidence-based advice.
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Additional info for A Practical Manual of Diabetic Retinopathy Management
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications 24 25 26 27 28 29 30 31 32 33 34 35 36 37 in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352(9131): 837–53. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352(9131): 854–65. UK Prospective Diabetes Study (UKPDS) Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38.
5 mmol/L in the plasma. Blood glucose concentrations above the normal limits lead to excessive glycosylation of proteins and this is probably one of the main aetiologies of the longterm complications of diabetes. In particular, the risks of hyperglycaemia and hypertension are multiplicative for microvascular disease, of which the commonest is diabetic retinopathy. CLASSIFICATION OF DIABETES Diabetes mellitus is generally divided into the categories ‘type 1 diabetes’ and ‘type 2 diabetes’, with much rarer A Practical Manual of Diabetic Retinopathy Management.
Because sustained hyperglycaemia is not a feature, those with MODY-2 rarely have macrovascular complications or significant retinopathy. Recent discoveries3,4 of ABCC8 (SUR1) and INS (insulin) gene mutations presenting in patients clinically defined as having MODY will have implications for clinical management. CASE HISTORY 3 HNF-1α MODY diabetes A 46-year-old man, who attended the eye clinic for monitoring of moderate non-proliferative diabetic retinopathy (preproliferative) was diagnosed with type 1 diabetes at the age of 18, having presented with a 4-month Fig.