Aging and Age Related Ocular Diseases (Ophthalmologica, 1) by E. Lütjen-Drecoll

By E. Lütjen-Drecoll

The phenomenon of getting older is characterised via a variety of degenerative alterations, which differentially have an effect on the hugely really expert constructions in the eye, resembling the merely mobile lens, the brain-derived retina and the connective tissue of the uvea and sclera. accordingly, the attention can function a very good version approach to review age-related degenerative illnesses. an outline article offers with the molecular biology of alpha-B-crystallin, and unique articles provide additional perception into the distribution and attainable useful value of nonlenticular alpha-B-crystallin. Retinal transplantation stories that can eventually bring about remedy for tapetoretinal degeneration and age-related macular degeneration are mentioned. additional, elements that impression the improvement of the retinal tissues are investigated. And one other assessment examines cells of the deep lens fibers. This exact factor is an in-depth resource of data to ophthalmologists in examine and perform.

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Reversal potential was hyperpolarized by 15 B 3 mV (n = 9). Tyrphostin 51, a synthetic inhibitor of tyrosine kinases, had the same effect (433 B 46%; n = 7). Daidzein, a nonactive structural analogue of genistein, had no effect (n = 4). The stimulation of outward current by tyrosine kinase inhibitors could be blocked by substitution of potassium by tetraethylammonium ions, while the potassium channel blockers glibenclamide (K-ATP) and apamin (small-conductance calcium-activated potassium channel) had no effect.

J Histochem Cytochem 1990;38: 31–39. 27 Lowe J, McDermott H, Pike I, Spendlove I, Landon M, Mayer RJ: Alpha B crystallin expression in non-lenticular tissues and selective presence in ubiquinated inclusion bodies in human disease. J Pathol 1992;166:61–68. 28 Kato S, Hirano A, Umahara T, Llena JF, Herz F, Ohama E: Ultrastructural and immunohistochemical studies on ballooned cortical neurons in Creutzfeldt-Jacob disease: Expression of alpha B-crystallin, ubiquitin and stress-response protein 27. Acta Neuropathol 1992;84: 443–448.

The rise in cytosolic calcium, especially in the compart- Stumpff/Wiederholt ment immediately under the cell membrane, should then activate calcium-dependent potassium channels, leading to repolarization in form of the downward stroke of the spike. This theory is validated by the fact that trabecular meshwork cells do indeed express calcium-dependent potassium channels in the form of maxi-K channels [121]. Interestingly, it could be shown that in trabecular meshwork, these channels are indeed insensitive to the application of external barium and should thus not be blocked by the barium necessary to evoke the spike.

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