By L. Robert, T. Fulop, T. Fulop
Getting older encouraged a lot of theories attempting to rationalize the getting older technique universal to all dwelling beings. during this book crucial environmental and intrinsic mechanisms enthusiastic about the getting older procedure and in its pathological effects are reviewed. moreover theoretical and experimental proof of crucial theoretical parts in accordance with Darwinian evolution, mobile getting older, position of telephone membranes, loose radicals and oxidative strategies, receptor-mediated reactions, the extracellular matrix and immune features in addition to crucial environmental and intrinsic mechanisms desirous about the getting older method and in its pathological effects are mentioned. those shows of theories and similar experimental proof provide a world review of contemporary ideas of the biology of the getting older procedure and are of crucial interpreting not just for experts during this box but in addition for practitioners of medical, scientific, social and experimental sciences.
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Additional resources for Aging: Facts and Theories, 1st Edition
7 Schneider EL, Fowlkes BJ: Measurement of DNA content and cell volume in senescent human ﬁbroblasts utilizing ﬂow multiparameter single cell analysis. Exp Cell Res 1976;98:298–302. 8 Ryan JM: The kinetics of chick cell populations aging in vitro. J Cell Phys 1979; 99:67–78. 9 Burmer GC, Norwood TH: Selective elimination of proliferating cells in human diploid cell cultures by treatment with BrdU, 33258 Hoechst and visible light. Mech Ageing Dev 1980;12: 151–159. 10 Pereira-Smith OM, Smith JR: Expression of SV40 antigen in ﬁnite-span hybrids of normal and SV40transformed ﬁbroblasts.
The SMART-MR study. Neurobiol Aging 2012; 33: 832 e15–e22. 48 Rusted JM, Evans SL, King SL, Dowell N, Tabet N, Tofts PS: APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures. Neuroimage 2013; 65: 364–373. 49 Giaimo S, d’Adda di Fagagna F: Is cellular senescence an example of antagonistic pleiotropy? Aging Cell 2012; 11:378–383. 50 Maison P, Balkau B, Simon D, Chanson P, Rosselin G, Eschwège E: Growth hormone as a risk for premature mortality in healthy subjects: data from the Paris prospective study.
After a given number of population doublings, cells enter a stage of irreversible growth arrest, which was called senescence. The ﬁrst experiments attempting to understand the kinetics of proliferation of these cell populations concluded that there is an entire spectrum of cells with different cycling probabilities, which evolve with an increasing heterogeneity [2–5]. Although most of the cells are able to divide through the proliferation life span, there is a constant decrease in the percent of cells capable of rapidly initiating the cycle, and an increase in the number of cells with long cycles.